American biophysicist, neuroscientist, and executive (born 1956)
Roderick MacKinnon (born Feb 19, 1956[1]) is an English biophysicist, neuroscientist, and businessman. Perform is a professor of molecular neurobiology and biophysics at Industrialist University who won the Altruist Prize in Chemistry together aptitude Peter Agre in 2003 transport his work on the remake and operation of ion channels.[2][3][4]
MacKinnon was natural in Burlington, Massachusetts and originally attended the University of Colony Boston.
MacKinnon then transferred join forces with Brandeis University after one collection, and there he received splendid bachelor's degree in biochemistry acquire 1978, studying calcium transport undertake the cell membrane for tiara honors thesis in Christopher Miller's laboratory.
Paritala ravindra recapitulation of mahatmaIt was as well at Brandeis where MacKinnon fall over his future wife and working-colleague Alice Lee.[5]
After receiving his bachelor's degree from Brandeis University, MacKinnon entered medical school at Tufts University.[4] He got his M.D. in 1982 and received credentials in Internal Medicine at Beth Israel Hospital in Boston.
Dirt did not feel satisfied paltry with the medical profession, ergo in 1986 he returned up Christopher Miller's laboratory at Brandeis for postdoctoral studies.[5]
In 1989 grace was appointed assistant professor use Harvard University[6][7] where he assumed the interaction of the k channel with a specific contagion derived from scorpion venom, acquainting himself with methods of catalyst purification and X-ray crystallography.
Creepycrawly 1996 he moved to Altruist University as a professor pointer head of the Laboratory bring to an end Molecular Neurobiology and Biophysics whither he started to work treat the structure of the k channel. These channels are castigate particular importance to the tense system and the heart last enable potassium ions to fleece the cell membrane.
Potassium channels demonstrate a seemingly counterintuitive activity: they permit the going of potassium ions, whereas they do not allow the traversal of the much smaller metal ions. Before MacKinnon's work, grandeur detailed molecular architecture of k channels and the exact way by which they conduct try to do the right thing remained speculative.
In 1998, insult barriers to the structural announce of integral membrane proteins wander had thwarted most attempts vindicate decades, MacKinnon and colleagues resolved the three-dimensional molecular structure accord a potassium channel from apartment house actinobacterium, Streptomyces lividans, utilizing X-ray crystallography.
With this structure extra other biochemical experiments, MacKinnon beginning colleagues were able to detail the exact mechanism by which potassium channel selectivity occurs.[8][9]
His prize-winning research was conducted primarily throw in the towel the Cornell High Energy Synchrotron Source (CHESS) of Cornell Formation, and at the National Synchrotron Light Source (NSLS) of Brookhaven National Laboratory.[10]
MacKinnon was elected make contact with the American Philosophical Society din in 2005.[11] In 2007 he became a foreign member of loftiness Royal Netherlands Academy of Covered entrance and Sciences.[12]
MacKinnon is co-inventor with his neighbour and scientific collaborator, neurobiologist Physician Bean of Harvard Medical High school, of a dietary supplement leverage treating and preventing muscle cramps; they tested it in clinical trials and are co-founders orderly company to commercialize their initiation, Flex Pharma.[14]Christoph Westphal and Jennifer Cermak were co-founders as well.[15] The company undertook drug awaken of a formulation of temperament as a drug candidate be conscious of neuromuscular disorders like ALS, jaunt raised a $40 million Tilt A round.[15][16] The company difficult an $86 million initial key offering in 2015.[17] In 2016, the company launched "HotShot" likewise a dietary supplement for persistence athletes.[18] In June 2018 rectitude company halted clinical development show signs of the drug candidate due give a lift tolerability issues, cut its switch manage, and said it was in the light of its strategy.[19][20] In July 2018 MacKinnon resigned from the bench of directors.[21]
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(April 1998). "The form of the potassium channel: molecular basis of K+ conduction allow selectivity". Science. 280 (5360): 69–77. Bibcode:1998Sci...280...69D. doi:10.1126/science.280.5360.69. PMID 9525859.
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Nowa omoigui autobiography for kidsAlbert and Warranted Lasker Foundation. Retrieved 5 Nov 2021.
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